Amlopress 5/Amlopress 10 Drug Interactions

Concomitant use of amlodipine with moderate (e.g., diltiazem) or potent (e.g., clarithromycin, itraconazole) inhibitors of cytochrome P-450 (CYP) 3A isoenzymes (CYP3A) results in increased systemic exposure to amlodipine. Reduction of amlodipine dosage may be necessary.
Concomitant administration of grapefruit juice with amlodipine did not alter systemic exposure to amlodipine.
Concomitant administration of amlodipine (multiple 10 mg) with simvastatin (80 mg) resulted in a 77% increase in simvastatin exposure compared with simvastatin alone. In patients receiving amlodipine, simvastatin dosage should not exceed 20 mg daily.
Concomitant use of CYP3A4 inducers (e.g., rifampicin, hypericum perforatum) may give a lower plasma concentration of amlodipine.
Concomitant use of alcohol with amlodipine did not alter systemic exposure to alcohol.
Concomitant administration of a magnesium- and aluminium antacid with amlodipine did not alter systemic exposure to amlodipine.
Concomitant administration of cimetidine with amlodipine did not alter systemic exposure to amlodipine.
Concomitant use of amlodipine with digoxin did not alter systemic exposure to digoxin.
Concomitant administration of amlodipine with atorvastatin did not alter systemic exposure to atorvastatin.
Concomitant administration of amlodipine with warfarin did not alter prothrombin time.